Overcoming Cannabinoid Solubility Challenges

Santé Laboratories has relevant and in-depth expertise in cannabinoid sciences and has successfully overcome formulation challenges to enable drug development opportunities.

Cannabinoids Are Poorly Water Soluble Compounds

The low water solubility inherent to cannabinoids creates formulation challenges that result in inadequate and inconsistent absorption after oral administration. Santé Laboratories has developed a lipid-based nanoparticle delivery system to enhance solubility and bioavailability of cannabinoids as well as other lipophilic compounds.

Regardless of phase in development and borrowing from relevant expertise in cannabinoid formulation sciences, Santé Laboratories can provide flexible drug delivery and manufacturing solutions to overcome solubility, room temperature stability, and absorption challenges to quickly transition into the clinic. In addition to leveraging the lipid-based nanoparticle delivery system, Santé Laboratories can perform rapid formulation screening studies which can be developed into candidate formulations to be evaluated in nonclinical and first-in-man studies. Experienced scientists at Santé Laboratories can support you with the following development services:

  • Characterize and qualify cannabinoid drug substances from synthetic, semi-synthetic, or plant extracts
  • Develop and optimize cannabinoid formulation candidates for nonclinical and first-in-man studies
  • Screen excipient compatibility and selection for optimal cannabinoid formulation
  • Evaluate chemical and physical stability of candidate cannabinoid formulations
  • Characterize finished product formulations using a variety of analytical techniques including drug release kinetics and nanoparticle analysis

Alternative Drug Delivery Solutions

Santé Laboratories has experience working with other proven formulation strategies with varying degrees of complexities to quickly overcome solubility challenges with cannabinoids including:

  • Liposomal delivery systems
  • Various lipid systems such as nanoemulsions and solid lipid nanoparticles
  • Self-Emulsifying Drug Delivery Systems (SEDDS)
  • Co-solvent-based formulations
  • Surfactant-based formulations
  • Cyclodextrin complex formulations
  • Spray-dried and lyophilized formulations