.journal_page__RL6QY{overflow-x:clip;padding-bottom:var(--sec-y)}.journal_crumbs__LZCyU{display:flex;gap:10px;align-items:center;flex-wrap:wrap;font-size:14px}.journal_crumbs__LZCyU a{color:var(--muted)}.journal_crumbs__LZCyU>span[aria-hidden]{color:var(--faint)}.journal_metaRow__MefNy{display:flex;gap:10px;align-items:center;flex-wrap:wrap}.journal_head__MFQ4R{padding-top:var(--sec-y);display:flex;flex-direction:column;gap:20px}.journal_headRow__2Q_8m{display:flex;flex-direction:column;gap:14px}.journal_lead__uT3jM{max-width:620px}.journal_chips__Msg8_{display:flex;gap:8px;flex-wrap:wrap}.journal_chips__Msg8_>li{flex:none}.journal_featWrap__1mPpz{padding-top:var(--sec-head)}.journal_feat__UHMwR{display:grid;grid-template-columns:1.25fr 1fr;overflow:hidden;padding:0}.journal_featSk__AOhsZ{height:480px;border-radius:var(--r-card,12px)}.journal_featImg__D8W1H{display:block;height:480px;border-radius:12px 0 0 12px}.journal_featBody__3NOEt{display:flex;flex-direction:column;justify-content:center;gap:18px;padding:var(--sec-card)}.journal_feat__UHMwR:hover .journal_featTitle__qg5sT{text-decoration:underline;text-underline-offset:6px;text-decoration-thickness:1px}.journal_featCta__WXAms{align-self:flex-start;margin-top:8px}.journal_list__5S4y8{padding-top:var(--sec-y);display:flex;flex-direction:column;gap:var(--sec-head)}.journal_listHead__WNF6M{display:flex;flex-wrap:wrap;justify-content:space-between;align-items:baseline;gap:16px}.journal_count__XiXQg:empty{display:none}.journal_grid__hSWd_{display:grid;grid-template-columns:repeat(3,minmax(0,1fr));-moz-column-gap:var(--sec-gap);column-gap:var(--sec-gap);row-gap:calc(var(--sec-y) / 2)}.journal_card__AJJDB{min-width:0}.journal_cardLink__o4O3i{display:flex;flex-direction:column;gap:14px;min-width:0}.journal_cardImg__w7vMF{display:block;height:260px;border-radius:12px;background:var(--well)}.journal_cardImg__w7vMF img{transition:transform .6s ease}.journal_cardLink__o4O3i:hover .journal_cardImg__w7vMF img{transform:scale(1.03)}.journal_cardDate__A8HgI{font-size:12px}.journal_cardLink__o4O3i:hover .journal_cardTitle__3vnGV{text-decoration:underline;text-underline-offset:4px;text-decoration-thickness:1px}.journal_pager__ECrlR{display:flex;justify-content:space-between;align-items:center;gap:12px;padding-top:28px;border-top:1px solid var(--line)}.journal_pagerOff__qesW_{opacity:.45;cursor:default}.journal_inlineError__BQWyk{display:flex;gap:14px;padding:var(--sec-card);align-items:flex-start}.journal_inlineError__BQWyk>div{display:flex;flex-direction:column;align-items:flex-start;gap:8px}.journal_state__xQuc4{padding:var(--sec-card);display:flex;flex-direction:column;align-items:center;text-align:center;gap:14px}.journal_state__xQuc4 .body{max-width:520px}.journal_skCard__C8Zpz{display:flex;flex-direction:column;gap:14px}.journal_skImg__EWBRE{height:260px;border-radius:12px}.journal_skLine1__TMQBY{height:18px;width:80%}.journal_skLine2__rTPu3{height:12px;width:60%}.journal_closeWrap__lBPE5{padding-top:var(--sec-y)}.journal_closeBand__9Ldpx{background:linear-gradient(160deg,color-mix(in srgb,var(--lab-ink) 92%,#000) 0,var(--lab-ink) 55%,color-mix(in srgb,var(--lab-ink) 80%,var(--mineral)) 100%)!important;color:var(--offwhite);padding:56px 64px;display:flex;align-items:flex-end;justify-content:space-between;gap:24px;flex-wrap:wrap}.journal_closeText__KyhJ8{min-width:0;overflow-wrap:anywhere;position:relative;z-index:1;display:flex;flex-direction:column;gap:10px;max-width:560px}.journal_closeEb__33rZ_{color:color-mix(in srgb,var(--offwhite) 75%,transparent)}.journal_closeTitle__mGv_o{color:var(--offwhite)}.journal_closeFoot__s__AG{font-size:16px;line-height:1.55;color:color-mix(in srgb,var(--offwhite) 90%,transparent)}.journal_closeActions__XsWIc{min-width:0;max-width:100%;position:relative;z-index:1;display:flex;gap:10px;flex-wrap:wrap}.journal_pillOnDark__bPmQh{color:var(--offwhite)!important;border-color:color-mix(in srgb,var(--offwhite) 55%,transparent)!important}.journal_pillOnDark__bPmQh:hover{border-color:var(--offwhite)!important}.journal_closeCard__Uuz7M{padding:var(--sec-card);display:flex;align-items:center;justify-content:space-between;gap:24px;flex-wrap:wrap}.journal_postHead__oB0Vn{padding-top:var(--sec-y);display:flex;flex-direction:column;gap:22px}.journal_postIntro__IKSQ3{max-width:980px;display:flex;flex-direction:column;gap:20px;padding-top:12px}.journal_postLead__4j5OP{max-width:760px}.journal_hero__RDrCe{margin:0;padding-top:var(--sec-head)}.journal_heroImg__FMikp{height:520px;background:var(--well)}.journal_heroCap__8bFLJ{padding-top:12px;max-width:760px}.journal_body__umODV{padding-top:calc(var(--sec-y) / 2);display:grid;grid-template-columns:260px minmax(0,1fr);gap:var(--sec-gap);align-items:start}.journal_tocCol__B5BPD{position:sticky;top:96px}.journal_articleCol__ImXTn{min-width:0}.journal_toc__ANOJk{display:flex;flex-direction:column}.journal_tocTitle__OqRXD{padding-bottom:10px}.journal_tocList__5_iLm{display:flex;flex-direction:column;gap:2px}.journal_tocList__5_iLm a{display:flex;gap:12px;padding:8px 0;font-size:14.5px;line-height:1.4;color:var(--ink-2)}.journal_tocList__5_iLm a.journal_tocOn__cnkTB,.journal_tocList__5_iLm a:hover{color:var(--ink)}.journal_tocNum__HJJCY{flex:none;font-size:12px;color:var(--muted);padding-top:1px}.journal_tocShare__NMciV{padding-top:24px}.journal_tocPhone__IGDR3{display:none;margin-bottom:28px;padding:16px 20px}.journal_tocPhone__IGDR3 summary{display:flex;justify-content:space-between;align-items:center;cursor:pointer;list-style:none}.journal_tocPhone__IGDR3 summary::-webkit-details-marker{display:none}.journal_tocPhone__IGDR3[open] summary svg{transform:rotate(180deg)}.journal_tocPhone__IGDR3 nav{padding-top:8px}.journal_article__o_QeD{display:flex;flex-direction:column;min-width:0}.journal_article__o_QeD>*+*{margin-top:14px}.journal_article__o_QeD>ol,.journal_article__o_QeD>p,.journal_article__o_QeD>ul{font-size:16px;line-height:1.55;color:var(--ink-2);text-wrap:pretty}.journal_article__o_QeD>h2{font-family:var(--disp);font-weight:400;font-size:24px;line-height:1.15;letter-spacing:.025em;text-transform:uppercase;color:var(--ink);margin-top:28px;scroll-margin-top:96px}.journal_article__o_QeD>h2:first-child{margin-top:0;padding-top:8px}.journal_article__o_QeD>h3{font-family:var(--disp);font-size:18px;font-weight:400;line-height:1.25;letter-spacing:.025em;text-transform:uppercase;color:var(--ink);margin-top:24px}.journal_article__o_QeD a{text-decoration:underline;text-underline-offset:4px;text-decoration-thickness:1px;text-decoration-color:var(--line-2)}.journal_article__o_QeD a:hover{text-decoration-color:var(--ink)}.journal_article__o_QeD strong{font-weight:600;color:var(--ink)}.journal_article__o_QeD>ol,.journal_article__o_QeD>ul{padding-left:22px;display:flex;flex-direction:column;gap:8px}.journal_article__o_QeD>ul{list-style:disc}.journal_article__o_QeD>ol{list-style:decimal}.journal_article__o_QeD>blockquote{margin:36px 0 8px;padding:8px 0 8px 24px;border-left:2px solid var(--lab-ink)}.journal_article__o_QeD>blockquote p{font-family:var(--disp);font-weight:400;font-size:24px;line-height:1.15;letter-spacing:.025em;text-transform:uppercase;color:var(--lab-ink)}.journal_article__o_QeD>figure:not([data-sample-figure]){margin:24px 0 8px;display:flex;flex-direction:column;gap:10px}.journal_article__o_QeD img{width:100%;height:auto;border-radius:12px}.journal_article__o_QeD figcaption{font-size:13px;line-height:1.45;color:var(--muted)}.journal_article__o_QeD table{width:100%;border-collapse:collapse;font-size:15px;margin:8px 0;display:block;overflow-x:auto}.journal_article__o_QeD td,.journal_article__o_QeD th{padding:12px 14px 12px 0;border-bottom:1px solid var(--line);text-align:left;vertical-align:top}.journal_article__o_QeD th{font-family:var(--mono);font-size:12px;font-weight:400;letter-spacing:.08em;text-transform:uppercase;color:var(--muted)}.journal_article__o_QeD hr{border:0;border-top:1px solid var(--line);margin:28px 0}.journal_article__o_QeD>details{border-bottom:1px solid var(--line);padding:18px 0}.journal_article__o_QeD>details+details{margin-top:0}.journal_article__o_QeD>details>summary{font-size:16px;color:var(--ink);cursor:pointer}.journal_article__o_QeD>details>:not(summary){margin-top:10px;font-size:16px;line-height:1.55;color:var(--ink-2)}.journal_article__o_QeD>.journal_disclaimer__GGaiX{margin-top:32px;padding-top:20px;border-top:1px solid var(--line)}.journal_article__o_QeD>.journal_sampleFig__iQhGW{margin:32px 0 8px;padding:var(--sec-card);display:flex;flex-direction:column;gap:14px}.journal_sampleHead__JtyhI,.journal_sampleValue__yCll_{display:flex;justify-content:space-between;align-items:center;gap:16px}.journal_sampleValue__yCll_{align-items:flex-end}.journal_sampleValue__yCll_ .fig{font-size:44px}.journal_sampleStatus__jht2A{align-self:flex-start;display:inline-flex;height:24px;align-items:center;padding:0 10px;border-radius:999px;font-size:12.5px;font-weight:500;background:color-mix(in srgb,var(--cell) 60%,var(--card));color:var(--cell-ink)}.journal_sampleStatus__jht2A[data-status=borderline]{background:color-mix(in srgb,var(--ion) 55%,var(--card));color:var(--ion-ink)}.journal_sampleStatus__jht2A[data-status=out]{background:color-mix(in srgb,var(--ion) 35%,var(--well));color:var(--ink)}.journal_sampleChart__wN0LV{display:flex;justify-content:center}.journal_sampleChart__wN0LV .ch-grid{stroke:var(--line);fill:none}.journal_sampleChart__wN0LV .ch-band{fill:var(--cell);opacity:.45}.journal_sampleChart__wN0LV .ch-line{stroke:var(--lab-ink);stroke-width:2;fill:none}.journal_sampleChart__wN0LV .ch-pt{fill:var(--lab-ink);stroke:var(--white);stroke-width:2}.journal_sampleChart__wN0LV .ch-pt-out{fill:var(--ink);stroke:var(--white);stroke-width:2}.journal_sampleChart__wN0LV .seg-out{fill:var(--ink)}.journal_sampleChart__wN0LV .ch-txt,.journal_sampleChart__wN0LV .ch-txt-b{font-family:var(--mono);font-size:11px;fill:var(--muted)}.journal_sampleChart__wN0LV .ch-txt-b{fill:var(--ink)}.journal_sampleFig__iQhGW figcaption .title{font-size:13px;margin-right:4px}.journal_measured__78Ka8{display:flex;flex-direction:column;gap:4px}.journal_measured__78Ka8>.eb{padding-bottom:6px}.journal_measuredRow__GrMes{display:flex;gap:14px;align-items:center;padding:12px 0;border-bottom:1px solid var(--line)}.journal_measuredThumb__y4ilg{flex:none;width:64px;height:64px}.journal_measuredRow__GrMes[data-availability=coming-soon] .journal_measuredThumb__y4ilg{opacity:.55}.journal_measuredText__rVA8Z{display:flex;flex-direction:column;align-items:flex-start;gap:4px;min-width:0}.journal_measuredName__nReAK{font-size:15px;font-weight:500}.journal_measuredRow__GrMes:hover .journal_measuredName__nReAK{text-decoration:underline;text-underline-offset:3px;text-decoration-thickness:1px}.journal_measuredAll__rD5a_{margin-top:16px;align-self:flex-start}.journal_keep___MXOR{padding-top:var(--sec-y);display:flex;flex-direction:column;gap:var(--sec-head)}.journal_keepHead__ARzyE{display:flex;justify-content:space-between;align-items:center;gap:16px}@media (max-width:1099px){.journal_feat__UHMwR{grid-template-columns:1fr 1fr}.journal_featImg__D8W1H,.journal_featSk__AOhsZ{height:400px}.journal_grid__hSWd_{grid-template-columns:repeat(2,minmax(0,1fr))}.journal_heroImg__FMikp{height:400px}.journal_body__umODV{grid-template-columns:minmax(0,1fr);gap:48px;max-width:760px}.journal_tocCol__B5BPD{display:none}.journal_tocPhone__IGDR3{display:block}.journal_closeBand__9Ldpx{padding:44px 36px}}@media (max-width:759px){.journal_filters__FnUnD>nav{min-width:0;max-width:100%;width:100%}.journal_chips__Msg8_{min-width:0;max-width:calc(100% + 2 * var(--ctr-pad));flex-wrap:nowrap;overflow-x:auto;scrollbar-width:none;margin:0 calc(-1 * var(--ctr-pad));padding:0 var(--ctr-pad)}.journal_chips__Msg8_::-webkit-scrollbar{display:none}.journal_feat__UHMwR{grid-template-columns:minmax(0,1fr)}.journal_featImg__D8W1H{height:240px;border-radius:12px 12px 0 0}.journal_featSk__AOhsZ{height:420px}.journal_featBody__3NOEt{gap:14px}.journal_grid__hSWd_{grid-template-columns:minmax(0,1fr)}.journal_cardImg__w7vMF,.journal_skImg__EWBRE{height:220px}.journal_pager__ECrlR{flex-wrap:wrap}.journal_pager__ECrlR .pill{padding:0 14px}.journal_closeBand__9Ldpx{padding:32px 20px}.journal_closeBand__9Ldpx,.journal_closeCard__Uuz7M{flex-direction:column;align-items:stretch}.journal_closeActions__XsWIc .pill{flex:1 1 auto}.journal_postHead__oB0Vn{gap:16px}.journal_postIntro__IKSQ3{gap:14px;padding-top:4px}.journal_heroImg__FMikp{height:240px}.journal_body__umODV{gap:40px}.journal_article__o_QeD>blockquote p,.journal_article__o_QeD>h2{font-size:20px}.journal_keepHead__ARzyE{flex-wrap:wrap}}.journal_filters__FnUnD{display:flex;justify-content:space-between;align-items:flex-start;gap:20px;flex-wrap:wrap}.journal_search__gXkXJ{display:flex;align-items:center;gap:10px;height:44px;padding:0 16px;border-radius:999px;border:1px solid var(--line-2);background:hsla(0,0%,100%,.45);color:var(--muted);min-width:260px}.journal_search__gXkXJ input{flex:1;min-width:0;border:0;background:transparent;font:inherit;font-size:14.5px;color:var(--ink);outline:none}.journal_search__gXkXJ input::-moz-placeholder{color:var(--faint)}.journal_search__gXkXJ input::placeholder{color:var(--faint)}.journal_searchClear__08Vni{border:0;background:transparent;font:inherit;font-size:20px;line-height:1;color:var(--muted);cursor:pointer}.journal_newsWrap__8QjA8{padding-top:var(--sec-y)}.journal_news__YqtSY{display:flex;flex-direction:column;gap:12px;padding:28px 32px;max-width:560px}.journal_newsField__dKJpf{display:flex;align-items:center;gap:10px;height:48px;padding:0 6px 0 18px;border-radius:999px;border:1px solid var(--line-2);background:var(--bg);opacity:.8}.journal_newsInput__NpAIJ{flex:1;min-width:0;border:0;background:transparent;font:inherit;color:var(--muted);outline:none}.journal_newsGo__Q_djE{display:inline-flex;align-items:center;justify-content:center;width:36px;height:36px;border-radius:999px;border:0;background:var(--well);color:var(--muted)}.journal_byline__hoLVr{display:flex;flex-wrap:wrap;gap:6px;align-items:center}.journal_reviewer__iC_lq{font-style:italic}.journal_answer__oycYm{display:flex;flex-direction:column;gap:8px;padding:20px 24px;border-left:3px solid var(--charcoal);max-width:720px}.journal_answer__oycYm .eb{color:var(--ink)}.journal_takeaways__137aY{display:flex;flex-direction:column;gap:12px;padding:22px 24px;margin-bottom:28px}.journal_takeaways__137aY ul{display:flex;flex-direction:column;gap:10px}.journal_takeaways__137aY li{position:relative;padding-left:22px;font-size:16px;line-height:1.55;color:var(--ink-2)}.journal_takeaways__137aY li:before{content:"";position:absolute;left:2px;top:.55em;width:6px;height:6px;border-radius:999px;background:var(--charcoal)}.journal_refs__Fw9D1{display:flex;flex-direction:column;gap:10px;margin-top:32px;padding-top:20px;border-top:1px solid var(--line)}.journal_refs__Fw9D1 ol{display:flex;flex-direction:column;gap:8px;padding-left:22px}.journal_refs__Fw9D1 li{font-size:13px;line-height:1.5;color:var(--muted);scroll-margin-top:96px}.journal_refs__Fw9D1 a{text-decoration:underline;text-underline-offset:3px}.journal_relatedBio__uQZ46{display:flex;flex-direction:column;gap:12px;margin-top:28px}.journal_relatedBio__uQZ46 ul{display:flex;flex-wrap:wrap;gap:8px}.journal_article__o_QeD a.ref-inline{font-family:var(--mono);font-size:.8em;padding:0 1px;color:var(--ink);text-decoration:none}.journal_measuredItem__9EAq9{display:flex;align-items:center;gap:8px}.journal_measuredItem__9EAq9 .journal_measuredRow__GrMes{flex:1;min-width:0}.journal_measuredMeta___AOeo{color:var(--muted)}.journal_measuredCta__iEW8Q{flex:none}@media (max-width:759px){.journal_filters__FnUnD{flex-direction:column;align-items:stretch}.journal_search__gXkXJ{min-width:0}.journal_answer__oycYm,.journal_takeaways__137aY{padding:18px}}@media (max-width:1099px),(pointer:coarse){.journal_crumbs__LZCyU a{display:inline-flex;align-items:center;min-width:44px;min-height:44px}}.biomarker_share__r_L13{display:flex;align-items:center;gap:10px}.biomarker_shareBtn__Iiqnd{width:36px;height:36px;border-radius:999px;border:1px solid var(--line-2);background:transparent;display:inline-flex;align-items:center;justify-content:center;color:var(--ink)}.biomarker_shareBtn__Iiqnd:hover{border-color:var(--ink)}.biomarker_shareRound__d6TMh{border-radius:999px}